Cerebellar vermis contributes to the extinction of conditioned fear.
Identifieur interne : 000292 ( Main/Exploration ); précédent : 000291; suivant : 000293Cerebellar vermis contributes to the extinction of conditioned fear.
Auteurs : A. Utz [Allemagne] ; M. Thürling [Allemagne] ; T M Ernst [Allemagne] ; A. Hermann [Allemagne] ; R. Stark [Allemagne] ; O T Wolf [Allemagne] ; D. Timmann [Allemagne] ; C J Merz [Allemagne]Source :
- Neuroscience letters [ 1872-7972 ] ; 2015.
English descriptors
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Abstract
The cerebellum is known to contribute to the acquisition and retention of conditioned motor and emotional responses. Eyeblink conditioning and fear conditioning have been studied in greatest detail. Whereas a considerable number of studies have shown that the cerebellum is also involved in extinction of conditioned eyeblink responses, the likely contribution of the cerebellum to extinction of conditioned fear responses has largely been ignored. In the present study, we analyzed functional brain imaging data (fMRI) of previous work investigating extinction of conditioned fear in 32 young and healthy men, in which event-related fMRI analysis did not include the cerebellum. This dataset was analyzed using a spatial normalization method optimized for the cerebellum. During fear acquisition, an unpleasant electric shock (unconditioned stimulus; US) was paired with one of two pictures of geometrical figures (conditioned stimulus; CS+), while the other picture (CS-) was never paired with the US. During extinction, CS+ and CS- were presented without the US. During the acquisition phase, the fMRI signal related to the CS+ was significantly higher in hemispheric lobule VI in early compared to late acquisition (p<.05, permutation corrected). During the extinction phase, the fMRI signal related to the contrast CS+>CS- was significantly higher within the anterior vermis in early compared to late extinction (p<.05, permutation corrected). The present data show that the cerebellum is not only associated with the acquisition but also with the extinction of conditioned fear.
DOI: 10.1016/j.neulet.2015.07.026
PubMed: 26219987
Affiliations:
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Utz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Thurling, M" sort="Thurling, M" uniqKey="Thurling M" first="M" last="Thürling">M. Thürling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Ernst, T M" sort="Ernst, T M" uniqKey="Ernst T" first="T M" last="Ernst">T M Ernst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Hermann, A" sort="Hermann, A" uniqKey="Hermann A" first="A" last="Hermann">A. Hermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Str. 10H, 35394 Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Str. 10H, 35394 Giessen</wicri:regionArea><wicri:noRegion>35394 Giessen</wicri:noRegion><wicri:noRegion>35394 Giessen</wicri:noRegion><wicri:noRegion>35394 Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Stark, R" sort="Stark, R" uniqKey="Stark R" first="R" last="Stark">R. Stark</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Str. 10H, 35394 Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychotherapy and Systems Neuroscience and Bender Institute of Neuroimaging, Justus Liebig University Giessen, Otto-Behaghel-Str. 10H, 35394 Giessen</wicri:regionArea><wicri:noRegion>35394 Giessen</wicri:noRegion><wicri:noRegion>35394 Giessen</wicri:noRegion><wicri:noRegion>35394 Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O T" last="Wolf">O T Wolf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, 44780 Bochum, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, 44780 Bochum</wicri:regionArea><wicri:noRegion>44780 Bochum</wicri:noRegion><wicri:noRegion>44780 Bochum</wicri:noRegion><wicri:noRegion>44780 Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Timmann, D" sort="Timmann, D" uniqKey="Timmann D" first="D" last="Timmann">D. Timmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany. Electronic address: dagmar.timmann-braun@uni-due.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Merz, C J" sort="Merz, C J" uniqKey="Merz C" first="C J" last="Merz">C J Merz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, 44780 Bochum, Germany; Department of Biological and Clinical Psychology, University of Trier, Johanniterufer 15, 54290 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, 44780 Bochum, Germany; Department of Biological and Clinical Psychology, University of Trier, Johanniterufer 15, 54290 Trier</wicri:regionArea><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuroscience letters</title><idno type="eISSN">1872-7972</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Brain Mapping</term><term>Cerebellar Vermis (physiology)</term><term>Conditioning, Classical</term><term>Extinction, Psychological</term><term>Fear</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebellar Vermis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Brain Mapping</term><term>Conditioning, Classical</term><term>Extinction, Psychological</term><term>Fear</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cerebellum is known to contribute to the acquisition and retention of conditioned motor and emotional responses. Eyeblink conditioning and fear conditioning have been studied in greatest detail. Whereas a considerable number of studies have shown that the cerebellum is also involved in extinction of conditioned eyeblink responses, the likely contribution of the cerebellum to extinction of conditioned fear responses has largely been ignored. In the present study, we analyzed functional brain imaging data (fMRI) of previous work investigating extinction of conditioned fear in 32 young and healthy men, in which event-related fMRI analysis did not include the cerebellum. This dataset was analyzed using a spatial normalization method optimized for the cerebellum. During fear acquisition, an unpleasant electric shock (unconditioned stimulus; US) was paired with one of two pictures of geometrical figures (conditioned stimulus; CS+), while the other picture (CS-) was never paired with the US. During extinction, CS+ and CS- were presented without the US. During the acquisition phase, the fMRI signal related to the CS+ was significantly higher in hemispheric lobule VI in early compared to late acquisition (p<.05, permutation corrected). During the extinction phase, the fMRI signal related to the contrast CS+>CS- was significantly higher within the anterior vermis in early compared to late extinction (p<.05, permutation corrected). The present data show that the cerebellum is not only associated with the acquisition but also with the extinction of conditioned fear.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Utz, A" sort="Utz, A" uniqKey="Utz A" first="A" last="Utz">A. Utz</name></noRegion><name sortKey="Ernst, T M" sort="Ernst, T M" uniqKey="Ernst T" first="T M" last="Ernst">T M Ernst</name><name sortKey="Hermann, A" sort="Hermann, A" uniqKey="Hermann A" first="A" last="Hermann">A. Hermann</name><name sortKey="Merz, C J" sort="Merz, C J" uniqKey="Merz C" first="C J" last="Merz">C J Merz</name><name sortKey="Stark, R" sort="Stark, R" uniqKey="Stark R" first="R" last="Stark">R. Stark</name><name sortKey="Thurling, M" sort="Thurling, M" uniqKey="Thurling M" first="M" last="Thürling">M. Thürling</name><name sortKey="Timmann, D" sort="Timmann, D" uniqKey="Timmann D" first="D" last="Timmann">D. Timmann</name><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O T" last="Wolf">O T Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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